HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 23324906, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethyl 2-pyrrolidinepropanoate | HCID 21600119 | — |
| Reactant | HCID 54267983 | HCID 54267983 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | HCID 23324906 | HCID 23324906 | — |
| Product | HCID 23324907 | HCID 23324907 | — |
Reaction Steps
A solution of 93.4 g of 5-oxo-3-[4-(trifluoromethyl)phenyl]-2-pyrrolidinepropanoic acid methyl ester and 5-oxo-β-[4-trifluoromethyl)phenyl]-2-pyrrolidinepropanoic acid ethyl ester in aqueous sodium hydroxide solution (1 N, 370 ml) is heated to 60° C. for four hours. Excess aqueous hydrochloric acid (1 N, 370 ml) is added and the solution is con25 centrated under reduced pressure to give 5-oxo-β-[4-(trifluoromethyl)phenyl]-2-pyrrolidinepropanoic acid and 5-oxo-3-[4-(trifluoromethyl)phenyl]-2-pyrrolidinepropanoic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04548947 |
| Source dataset | uspto-grants-1985_10 |
| ORD ID | ord-71ceecc074e44e2084aefb7cd093ea9f |
| Source note | uspto-grants-1985_10 |