反应详情

A suspension of 40 g of 2-(4-methoxyphenylamino)benzoic acid in 200 ml of ethyl chloroformate was heated at reflux for 24 hours. The reaction mixture was cooled in an ice-bath and the solid which separated was collected by filtration to give 31 g of N-(4-methoxyphenyl)isatoic anhydride after 6 hours of drying in a vacuum oven. An additional 9 g of product was obtained by concentration of the filtrate in vacuo.

1. temperaturewas heated
2. temperatureat reflux for 24 hours
3. temperatureThe reaction mixture was cooled in an ice-bath
4. customthe solid which separated
5. filtrationwas collected by filtration