Phosgene → HCID 54060996, compound

HRID 464794Notes

Reaction equation

HRID 464794 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15][C:16]2[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][C:17]=2[C:18]([OH:20])=[O:19])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:27](Cl)(Cl)=[O:28]>>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([N:15]2[C:27](=[O:28])[O:20][C:18](=[O:19])[C:17]3=[CH:21][C:22]([O:25][CH3:26])=[CH:23][CH:24]=[C:16]23)=[CH:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 6371PhosgeneHCID 133714622-[4-(Benzyloxy)anilino]-5-methoxybenzoic acid

Product 1

HCID 54060996HCID 54060996, compoundYield 79%

Procedure

N-(4-Benzyloxyphenyl)-5-methoxyisatoic anhydride [VIII; R=5-CH3O, R"=H, OR°=4-OCH2C6H5 ] was prepared from 2-(4-benzyloxyphenylamino)-5-methoxybenzoic acid and phosgene according to the procedure of Example 1, part (b), and was obtained in 79% yield as a colorless solid used directly in the next reaction.

Workup

  1. customwas obtained in 79% yield as a colorless solid
  2. customused directly in the next reaction

Sources & evidence

ORD record
ord-36f04b44812b489eb81179d1553caf61
Source dataset
uspto-grants-1985_10
Patent number
US04549016

Reaction notes

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