Phosgene → HCID 20262586, compound

Participants

Reaction Steps

It is contemplated that the foregoing product by reaction with phosgene or ethyl chloroformate can be converted to N-(4-methoxy-2-methylphenyl)isatoic anhydride [VIII; R=H, R"=2-CH3, OR°=4-OCH3 ], and the latter reacted with piperidine to give 1-[2-(4-methoxy-2-methylphenylamino)benzoyl]piperidine [IX; R=H, R"=2-CH3, N=Z=1-piperidinyl, OR°=4-OCH3 ] which can be de-etherified with boron tribromide to yield 1-[2-(4-hydroxy-2-methylphenylamino)benzoyl]piperidine [I; R and R'=H, R"=2-CH3, N=Z=1-piperidinyl, OH at 4-position].

Provenance & Evidence