HCID 70045199, compound → HCID 70046819, compound

Participants

Reaction Steps

In 100 ml of ethanol is dissolved 0.7 g of benzyl 3(S)-[1(R)-ethoxycarbonyl-3-phenylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetate hydrochloride obtained in Example 16, and catalytic reduction is conducted at ordinary temperature and under atmospheric pressure using 0.5 g 10% palladium-carbon (containing 50% moisture) as a catalyst, when the absorption of hydrogen stops, the catalyst is filtered off and the filtrate is concentrated under reduced pressure. Petroleum ether is added to the residue to give 0.53 g of 3(S)-[1(R)-ethoxycarbonyl-3-phenylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid hydrochloride as a colorless powder.

Provenance & Evidence