Potassium Iodide → HCID 70047673, compound

Participants

Reaction Steps

In 10 ml of N,N-dimethylformamide is dissolved 0.25 g of tert-butyl 3(S)-[1(S)-carboxy-3-cyclohexylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetate obtained in Example 50, and benzyl bromide (0.14 g), sodium bicarbonate (0.7 g) and potassium iodide (0.05 g) are added to the solution. The reaction solution is stirred at room temperature for 6 hours and diluted with water (100 ml) and extracted with ethyl acetate. The extract is washed successively with 1N hydrochloric acid and water, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The oily product is purified by silica gel column chromatography (hexane:ethyl acetate=5:1) to give 0.25 g of tert-butyl 3(S)-[1(S)-benzyloxycarbonyl-3-cyclohexylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetate as a colorless oil.

Provenance & Evidence