Hydrochloric Acid → HCID 53990245, compound

Participants

Reaction Steps

In 1 ml of ethanol is dissolved 0.2 g of 3(S)-[1(S)-ethoxycarbonyl-3-cyclohexylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid obtained in Example 54, and 3 ml of 1N sodium hydroxide solution is added to the solution. After stirring at room temperature for 2 hours, the solution is acidified slightly with 1N hydrochloric acid. The deposited crystals are collected by filtration, washed with water, dried and recrystallized from ethanol to give 0.14 g of 3(S)-[1(S)-carboxy-3-cyclohexylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid as colorless crystals, melting at 202°-205° C.

Provenance & Evidence