HCID 13622588, compound → HCID 13622612, compound

HRID 464860Notes

Reaction equation

HRID 464860 reaction equation
C(OC([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C@H:16]([NH:22][C@@H:23]1[C:29](=[O:30])[N:28]([CH2:31][C:32]([O:34]C(C)(C)C)=[O:33])[C:27]2[CH:39]=[CH:40][CH:41]=[CH:42][C:26]=2[O:25][CH2:24]1)[C:17]([O:19][CH2:20][CH3:21])=[O:18])=O)(C)(C)C.C(OCC)(=O)C.[ClH:49]>>[ClH:49].[ClH:49].[NH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C@H:16]([NH:22][C@@H:23]1[C:29](=[O:30])[N:28]([CH2:31][C:32]([OH:34])=[O:33])[C:27]2[CH:39]=[CH:40][CH:41]=[CH:42][C:26]=2[O:25][CH2:24]1)[C:17]([O:19][CH2:20][CH3:21])=[O:18]

Participants

3

Reactant 2

HCID 13622588HCID 13622588, compoundHCID 21866389Hydrogen chloride-ethyl acetate

Product 1

HCID 13622612HCID 13622612, compound

Procedure

A mixture of tert-butyl 3(S)-[8-tert-butoxycarbonylamino-1(S)-ethoxycarbonyloctyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetate (0.45 g) and 5N hydrogen chloride-ethyl acetate solution (10 ml) is allowed to stand for 3.5 hours at room temperature. The mixture is diluted with petroleum ether (80 ml) to precipitate colorless powder, which is collected and dried in vacuo to give 3(S)-[8-amino-1(S)-ethoxycarbonyloctyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid.dihydrochloride (0.37 g).

Workup

  1. customto precipitate colorless powder, which
  2. customis collected
  3. customdried in vacuo

Sources & evidence

ORD record
ord-e744ccecd00045baad7754fc436ae5a3
Source dataset
uspto-grants-1985_10
Patent number
US04548932

Reaction notes

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