2-((4-Methyl-5-imidazolyl)methylthio)ethylthiourea → HCID 178433689, compound

HRID 46487Notes

Reaction equation

HRID 46487 reaction equation
Cl[CH2:2][CH2:3][S:4][CH2:5][C:6]1[N:7]=[CH:8][NH:9][C:10]=1[CH3:11].[CH3:12][C:13]1[NH:17][CH:16]=[N:15][C:14]=1[CH2:18][S:19][CH2:20][CH2:21][NH:22][C:23]([NH2:25])=[S:24]>C(O)C>[CH3:12][C:13]1[NH:17][CH:16]=[N:15][C:14]=1[CH2:18][S:19][CH2:20][CH2:21][NH:22][C:23](=[NH:25])[S:24][CH2:2][CH2:3][S:4][CH2:5][C:6]1[N:7]=[CH:8][NH:9][C:10]=1[CH3:11]

Participants

4

Reactant 2

HCID 127186972-((4-Methyl-5-imidazolyl)methylthio)ethylthioureaHCID 132173604-{[(2-Chloroethyl)sulfanyl]methyl}-5-methyl-1H-imidazole

Product 1

HCID 178433689HCID 178433689, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1-Chloro-2-(5-methyl-4-imidazolylmethylthio)ethane and N-[2-(5-methyl-4-imidazolylmethylthio)ethyl]thiourea are heated together at reflux temperature in ethanol, and the mixture is evaporated and the residue purified to give the title compound, which may be converted into a suitable salt by ion-exchange chromatography.

Workup

  1. customthe mixture is evaporated
  2. customthe residue purified

Sources & evidence

ORD record
ord-808b65fad5f346f6b02d1a3aae6619a5
Source dataset
uspto-grants-1979_11
Patent number
US04173644

Reaction notes

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