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(E)-5-Dimethylamino-1-phenyl-pent-1-en-3-one; hydrochloride → 5-(Dimethylamino)-3-hydroxy-1-phenyl-1-pentene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (E)-5-Dimethylamino-1-phenyl-pent-1-en-3-one; hydrochloride | HCID 145789 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Methanol--water (1/1) | HCID 22242641 | — |
| 生成物 | 5-(Dimethylamino)-3-hydroxy-1-phenyl-1-pentene | HCID 54514102 | 89.3% |
反応手順
5-(Dimethylamino)-1-phenyl-1-penten-3-one, hydrochloride (1:1) (18.6 g, 0.078 mole) is dissolved in 200 ml 1:1 methanol-water. Sodium bicarbonate (2.0 g) is added, followed by the portionwise addition of NaBH4 (3.0 g) at 35° C. After addition, the reaction mixture is stirred for 2 hours at room temperature. This solution is diluted with 200 ml of water and organics are extracted with ether. The ether is dried with MgSO4, filtered and concentrated in vacuo to yield 14.3 g of product. IR consistent.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04173649 |
| 出典データセット | uspto-grants-1979_11 |
| ORD ID | ord-e03dceb46aca4a64826561499e8e0c0e |
| 出典メモ | uspto-grants-1979_11 |