HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium borohydride → 4-(4-Chlorophenylmercapto)-3,3-dimethyl-1-(imidazol-1-yl)-butan-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 1-Bromo-4-[(4-chlorophenyl)sulfanyl]-3,3-dimethylbutan-2-one | HCID 12765974 | — |
| Reactant | 4-[(4-Chlorophenyl)sulfanyl]-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one | HCID 13064958 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-(4-Chlorophenylmercapto)-3,3-dimethyl-1-(imidazol-1-yl)-butan-2-ol | HCID 13064959 | 91% |
Reaction Steps
0.3 g (0.0079 mol) of sodium borohydride in 8 ml of water was added dropwise to 7 g (0.024 mol) of 4-(4-chlorophenylmercapto)-3,3-dimethyl-1-(imidazol-1-yl)-butan-2-one, compound 6 of Example 6 hereinabove, at room temperature. The reaction mixture was subsequently stirred at room temperature for 1 hour and was poured onto water. The crystals which had precipitated were filtered off, and dried at 50° C. in vacuo. 6.5 g (91% of theory) of 4-(4-chlorophenylmercapto)-3,3-dimethyl-1-(imidazol-1-yl)-butan-2-ol of melting point 109°-110° C. were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04549900 |
| Source dataset | uspto-grants-1985_10 |
| ORD ID | ord-f2860da034b04dc89e389f04cc234cd7 |
| Source note | uspto-grants-1985_10 |