Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Benzoyl chloride, 3-nitro- | HCID 8495 | — |
| Reactant | Hydrazinecarboxaldehyde, 2-(4-aminophenyl)- | HCID 113189 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 14150245 | HCID 14150245 | 64.3% |
Reaction Steps
68.2 g of 1-formyl-2-(4-aminophenyl)hydrazine and 60 ml of triethylamine were dissolved in 500 ml of acetonitrile. To the resulting solution, 70 g of 3-nitrobenzoyl chloride was added dropwise with stirring while keeping the solution temperature at less than 50° C., by which crystals precipitated. After being heated to 60° C. for a further 2 hours, it was cooled and poured into water. Crystals were filtered off and recrystallized from ethanol to obtain 72.8 g of 1-formyl-2-(4-(3-nitrobenzamido)phenyl)hydrazine. Yield: 54%. Melting point: 185°-187° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04550070 |
|---|
| Source dataset | uspto-grants-1985_10 |
|---|
| ORD ID | ord-51a3d21d64e74489a470540616b5c17d |
|---|
| Source note | uspto-grants-1985_10 |
|---|
