(1-Benzyl-pyrrolidin-3-ylmethyl)-isopropyl-amine → N-(Pyrrolidin-3-ylmethyl)propan-2-amine

Participants

Reaction Steps

A mixture of 13.4 g (58.0 mmol) of 1-phenylmethyl-N-(2-propyl)-3-pyrrolidinemethanamine, 1.0 g of 20% palladium on carbon and 130 ml of methanol was shaken in an atmosphere of hydrogen at about 50 psi and room temperature for 24 hours. The catalyst was removed by filtration through Celite; the filtrate concentrated and distilled in vacuo to give 6.3 g of N-(2-propyl)-3-pyrrolidinemethanamine, bp 58°-60° C. (3.5 mm).

Provenance & Evidence