HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Benzyl-7-methyl-2,7-diazaspiro[4.4]nonane Dihydrochloride → 2-Methyl-2,7-diazaspiro[4.4]nonane dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Benzyl-7-methyl-2,7-diazaspiro[4.4]nonane Dihydrochloride | HCID 2868837 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-Methyl-2,7-diazaspiro[4.4]nonane dihydrochloride | HCID 13491806 | — |
Reaction Steps
A solution of 7-benzyl-2-methyl-2,7-diazaspiro-[4.4]nonane dihydrochloride in 150 ml of methanol with 1.0 g 20% palladium on carbon catalyst was hydrogenated at 4.5×105Pa for two days. After filtration, the filtrate was concentrated to a thick syrup which crystallized on addition of acetonitrile to give 11.5 g of 2-methyl-2,7-diazaspiro[4.4]nonane dihydrochloride, softened at 164° C. and melted at 168°-170° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04550104 |
| Source dataset | uspto-grants-1985_10 |
| ORD ID | ord-8c7f6439cfa444899b201f107d18c13d |
| Source note | uspto-grants-1985_10 |