HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Ether → 3-(1,2-Dihydro-2-naphthalenyl)-1-methylpyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-(1,2-Dihydro-2-naphthalenyl)-1-methyl-2,5-pyrrolidinedione | HCID 20387359 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3-(1,2-Dihydro-2-naphthalenyl)-1-methylpyrrolidine | HCID 20387367 | — |
Reaction Steps
The 3-(1,2-dihydro-2-naphthalenyl)-1-methyl-2,5-pyrrolidinedione, 60 g, is taken up in dioxane and added dropwise to a suspension of 40 g of lithium aluminum anhydride (LAH) in 2 l. diethyl ether. After 5 hours at reflux, the mixture is decomposed with K2CO3 solution and filtered. Evaporation of the organic layer leaves 42.8 g of 3-(1,2-dihydro-2-naphthalenyl)-1-methylpyrrolidine which is distilled at 125°-150°/0.2 mm IR and NMR consistent, 28 g yield (54%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04173640 |
| Source dataset | uspto-grants-1979_11 |
| ORD ID | ord-0ffd36cad68a4ccbaa74fbfc5643cc59 |
| Source note | uspto-grants-1979_11 |