2-[2-(3-Hydroxy-1,2,3,4-tetrahydronaphthalenyl)ethyl]-1-methylpiperidine → 2-[2-(1,2,3,4,5,8-Hexahydro-3-hydroxynaphthalenyl)ethyl]-1-methylpiperidine

HRID 46502Notes

Reaction equation

HRID 46502 reaction equation
[OH:1][CH:2]1[CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]([CH2:12][CH2:13][CH:14]2[CH2:19][CH2:18][CH2:17][CH2:16][N:15]2[CH3:20])[CH2:3]1.OC1C(O)C2C(=CC=CC=2)CC1C1CCN(C)C1>>[OH:1][CH:2]1[CH2:11][C:10]2[CH2:9][CH:8]=[CH:7][CH2:6][C:5]=2[CH:4]([CH2:12][CH2:13][CH:14]2[CH2:19][CH2:18][CH2:17][CH2:16][N:15]2[CH3:20])[CH2:3]1

Participants

3

Reactant 2

HCID 203873622-[2-(3-Hydroxy-1,2,3,4-tetrahydronaphthalenyl)ethyl]-1-methylpiperidineHCID 203873713-(3,4-Dihydroxy-1,2,3,4-tetrahydro-2-naphthalenyl)-1-methylpyrrolidine

Product 1

HCID 203873882-[2-(1,2,3,4,5,8-Hexahydro-3-hydroxynaphthalenyl)ethyl]-1-methylpiperidine

Procedure

Following the procedure of Example 6, part D, but substituting the 2-[2-(3-hydroxy-1,2,3,4-tetrahydronaphthalenyl)ethyl]-1-methylpiperidine for the 3-(3,4-dihydroxy-1,2,3,4-tetrahydro-2-naphthalenyl)-1-methylpyrrolidine, the title E compound is obtained.

Workup

  1. customthe title E compound is obtained

Sources & evidence

ORD record
ord-0c7d80c4f5134c718356c3ac04c54bdb
Source dataset
uspto-grants-1979_11
Patent number
US04173640

Reaction notes

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