HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl Sulfate → 2-(3-Hydroxy-1,2,3,4-tetrahydronaphthalenyl)-1-methylpiperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl Sulfate | HCID 6497 | — |
| Reactant | 2-(3-Hydroxy-1,2,3,4-tetrahydronaphthalenyl)-pyridine | HCID 20387380 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Catalyst | Adams' catalyst | HCID 345198 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 2-(3-Hydroxy-1,2,3,4-tetrahydronaphthalenyl)-1-methylpiperidine | HCID 20387370 | — |
Reaction Steps
The 2-(3-hydroxy-1,2,3,4-tetrahydronaphthalenyl)-pyridine thus obtained is quaternized with dimethyl sulfate on the steam bath neat. After several hours, the salt is dissolved in HOAc and reduced over a mixture of PtO2 and Pd/C to yield 2-(3-hydroxy-1,2,3,4-tetrahydronaphthalenyl)-1-methyl piperidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04173640 |
| Source dataset | uspto-grants-1979_11 |
| ORD ID | ord-2c2e83e84a6049d492ca1f0b4ece8da6 |
| Source note | uspto-grants-1979_11 |