Potassium Carbonate → HCID 178484977, compound

Participants

Reaction Steps

A methanol solution (50 ml) containing 5-[(2-aminoethyl)thiomethyl]benzimidazole.dihydrobromide (4.2 g) prepared in item (A) above, dimethyl dithiocyanoimidocarbonate (1.75 g) and potassium carbonate (1.65 g) was agitated for 16 hrs at room temperature. After removal of the solid component, the solvent was distilled off. Then, a 20% methylamine in methanol (45 ml) was added to the residue, and the mixture was agitated for 16 hrs at room temperature. The solvent was distilled off under reduced pressure, and the oily residue was subjected to column chromatography using silica gel as a filler and an ethyl acetate/methanol (7:1) mixture as a developer. Then, N-cyano-N'-methyl-N"-[2-(5-benzimidazolylmethylthio)ethyl]guanidine (mp. 191.4° C., 2.46 g, 75%) was obtained.

Provenance & Evidence