Thionyl Chloride → HCID 20261653, compound

Participants

Reaction Steps

5-Chloromethyl-2-dimethylaminomethylbenzimidazole, 2hydrochloride (melting point 248.4° C., 3.64 g) was produced by subjecting 2-dimethylaminomethyl-5-hydroxymethylbenzimidazole (3 g) and thionylchloride (10.5 ml) to a 4-hour refluxing with heat. 2-Mercaptopropionitrile (1.05 g) was changed into sodium salt by sodium ethoxide and, at a temperature of 0° C., methanol solution of the above-mentioned chloromethyl compound was added gradually and the mixture was stirred through one whole night at the room temperature to yield 5-[(2-cyanoethyl)thiomethyl]-2-dimethylaminomethylbenzimidazole (3.2 g).

Provenance & Evidence