4-((Piperidin-2-yl)methyl)morpholine → 5,10-Dihydro-5-[[2-[(4-morpholinyl)methyl]-1-piperidinyl]-acetyl]-11H-dibenzo[b,e][1,4]diazepin-11-one

HRID 465063Notes

Reaction equation

HRID 465063 reaction equation
Cl[CH2:2][C:3]([N:5]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[C:9](=[O:16])[NH:8][C:7]2[CH:17]=[CH:18][CH:19]=[CH:20][C:6]1=2)=[O:4].[N:21]1([CH2:27][CH:28]2[CH2:33][CH2:32][CH2:31][CH2:30][NH:29]2)[CH2:26][CH2:25][O:24][CH2:23][CH2:22]1>>[N:21]1([CH2:27][CH:28]2[CH2:33][CH2:32][CH2:31][CH2:30][N:29]2[CH2:2][C:3]([N:5]2[C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=3[C:9](=[O:16])[NH:8][C:7]3[CH:17]=[CH:18][CH:19]=[CH:20][C:6]2=3)=[O:4])[CH2:26][CH2:25][O:24][CH2:23][CH2:22]1

Participants

3

Reactant 2

HCID 31633954-((Piperidin-2-yl)methyl)morpholineHCID 100854195-(chloroacetyl)-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one

Product 1

HCID 135785615,10-Dihydro-5-[[2-[(4-morpholinyl)methyl]-1-piperidinyl]-acetyl]-11H-dibenzo[b,e][1,4]diazepin-11-one

Procedure

The title compound is prepared analogously to Example 2 from 5-(chloroacetyl)-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one and 2-[(4-morpholinyl)methyl]piperidine to give colorless crystals, mp. 194°-195° C. (after recrystallisation from diisopropyl ether and acetonitrile using activated charcoal).

Workup

  1. customto give colorless
  2. customcrystals, mp. 194°-195° C. (after recrystallisation from diisopropyl ether and acetonitrile using activated charcoal)

Sources & evidence

ORD record
ord-cac1f724681d48ceac4b874454fa2cf6
Source dataset
uspto-grants-1985_10
Patent number
US04550107

Reaction notes

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