HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(2-Piperidylmethyl)-dimethylamine → 4,9-Dihydro-4-[[2-[(dimethylamino)methyl]-1-piperidinyl]-acetyl]-10H-thieno[3,4-b][1,5]benzodiazepin-10-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(2-Piperidylmethyl)-dimethylamine | HCID 252484 | — |
| Reactant | 4-chloroacetyl-9,10-dihydro-4H-thieno[3,4-b][1,5]benzodiazepin-10-one | HCID 20063899 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4,9-Dihydro-4-[[2-[(dimethylamino)methyl]-1-piperidinyl]-acetyl]-10H-thieno[3,4-b][1,5]benzodiazepin-10-one | HCID 13578566 | — |
Reaction Steps
The title compound is prepared analogously to Example 2 from 4-(chloroacetyl)-4,9-dihydro-10H-thieno[3,4-b][1,5]benzodiazepin-10-one and 2-[(dimethylamino)methyl]piperidine to give colorless crystals, Mp. 208°-209° C. (acetonitrile/activated charcoal).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04550107 |
| Source dataset | uspto-grants-1985_10 |
| ORD ID | ord-35d5744ad2274bde9a8b5adb206f5559 |
| Source note | uspto-grants-1985_10 |