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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 465070Generated: October 25, 2026

11-(Chloroacetyl)-5,11-dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-one → 11-(2-(2-((Diethylamino)methyl)-1-piperidinyl)acetyl)-5,11-dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-one

https://huagongshe.com/reaction/465070

Reaction equation

Participants

RoleNameHCIDCharge
Reactant11-(Chloroacetyl)-5,11-dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-oneHCID 120053—
ReactantN,N-Diethyl-2-piperidinemethanamineHCID 254287—
Solvent1-PropanolHCID 1031—
Product11-(2-(2-((Diethylamino)methyl)-1-piperidinyl)acetyl)-5,11-dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-oneHCID 107867—

Reaction Steps

The title compound is prepared analogously to Example 2 from 11-(chloroacetyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and 2-[(diethylamino)methyl]piperidine to give colorless crystals, Mp. 225°-225.5° C. (n-propanol).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04550107
Source datasetuspto-grants-1985_10
ORD IDord-152ea72b3693480d84ed60a8d5b30491
Source noteuspto-grants-1985_10