HuagongsheHuagongshe Chemistry Print Report · For research reference only
11-(Chloroacetyl)-5,11-dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-one → (S)-11-[[2-[(Diethylamino)methyl]-1-pyrrolidinyl]-acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 11-(Chloroacetyl)-5,11-dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-one | HCID 120053 | — |
| Reactant | (S)-N-Ethyl-N-(pyrrolidin-2-ylmethyl)ethanamine | HCID 7141622 | — |
| Reactant | Ethylacetate methanol | HCID 21584119 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (S)-11-[[2-[(Diethylamino)methyl]-1-pyrrolidinyl]-acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one | HCID 13578573 | — |
Reaction Steps
The title compound is prepared analogously to Example 31 from 11-(chloroacetyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and (S)-(+)-2-[(diethylamino)methyl]pyrrolidine to give colorless crystals, mp. 192°-193° C. (ethyl acetate/methanol 99:1 v/v); [α]D20 =29.4° (ethanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04550107 |
| Source dataset | uspto-grants-1985_10 |
| ORD ID | ord-3a4062283f4c495f9d8e3ae4dff28bd9 |
| Source note | uspto-grants-1985_10 |