HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-(+)-1-(2-Pyrrolidinylmethyl)pyrrolidine → (S)-5,10-Dihydro-5-[[2-[(1-pyrrolidinyl)methyl]-1-pyrrolidinyl]-acetyl]-11H-dibenzo[b,e][1,4]diazepin-11-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-(+)-1-(2-Pyrrolidinylmethyl)pyrrolidine | HCID 853152 | — |
| Reactant | 5-(chloroacetyl)-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one | HCID 10085419 | — |
| Reactant | Ethylacetate methanol | HCID 21584119 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | (S)-5,10-Dihydro-5-[[2-[(1-pyrrolidinyl)methyl]-1-pyrrolidinyl]-acetyl]-11H-dibenzo[b,e][1,4]diazepin-11-one | HCID 13578582 | — |
Reaction Steps
The title compound is prepared analogously to Example 31 from 5-(chloroacetyl)-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one and (S)-(+)-2-[(1-pyrrolidinyl)methyl]pyrrolidine to give colorless crystals, mp. 142°-144° C. (ethyl acetate/methanol 99:1 v/v); [α]D20 =-18.5° (ethanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04550107 |
| Source dataset | uspto-grants-1985_10 |
| ORD ID | ord-de69ce0406ca495f95227adef4c41e52 |
| Source note | uspto-grants-1985_10 |