HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(2-Piperidylmethyl)-dimethylamine → N,N-Diethyl-2-piperidinemethanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(2-Piperidylmethyl)-dimethylamine | HCID 252484 | — |
| Reactant | D-Tartaric acid | HCID 439655 | — |
| Reactant | (S)-(-)-1-Phenylethyl isocyanate | HCID 2724173 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N,N-Diethyl-2-piperidinemethanamine | HCID 254287 | — |
Reaction Steps
The title compound is prepared analogously to Example 52(a) from racemic 2-[(dimethylamino)methyl]piperidine and D-(-)-tartaric acid. The ditartrate melted at 191°-192.5° C. The base, with a boiling point 17 mm Hg 88°-94° C., had a content of (+)-enantiomer determined by reaction with (S)-(-)-1-phenylethylisocyanate and subsequent HPLC investigation, of 98.5%. [α]D20 =+64° (ethanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04550107 |
| Source dataset | uspto-grants-1985_10 |
| ORD ID | ord-0e6a4e9707a44479b70828a2bf347344 |
| Source note | uspto-grants-1985_10 |