Piperidine → 4,9-Dihydro-4-[[2-[(dimethylamino)methyl]-1-piperidinyl]-acetyl]-3-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one

Participants

Role	Name	HCID	Charge
Reactant	Piperidine	HCID 8082	—
Reactant	4-chloroacetyl-9,10-dihydro-3-methyl-4H-thieno[3,4-b][1,5]benzodiazepin-10-one	HCID 19804218	—
Solvent	Cyclohexane ethylacetate	HCID 21867204	—
Product	4,9-Dihydro-4-[[2-[(dimethylamino)methyl]-1-piperidinyl]-acetyl]-3-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one	HCID 20261519	—

Reaction Steps

The title compound is prepared analogously to Example 2 from 4-(chloroacetyl)-4,9-dihydro-3-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one and 2-(dimethylamino)methyl]piperidine to give colorless crystals, mp. 172°-173° C. (cyclohexane/ethyl acetate 4:1 v/v).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US04550107
Source dataset	uspto-grants-1985_10
ORD ID	ord-6c497de96d6f443d92affb185a48dea6
Source note	uspto-grants-1985_10