反应详情

The solution of 50 g of 2-cyanomethyl-6-methoxy-1-tetralone in 1000 ml of ethanol is hydrogenated in the presence of 15 g of Raney nickel at atmospheric pressure and room temperature until 2 mole equivalents of hydrogen are consumed. The mixture is filtered, the filtrate evaporated and the crude product dissolved in 500 ml of N hydrochloric acid. The solution is washed with diethyl ether, treated with charcoal, filtered and the filtrate is basified with 3 N aqueous sodium hydroxide. It is extracted with methylene chloride, the extract dried, evaporated, the residue crystallized from petroleum ether and recrystallized from hexane, to yield the 7-methoxy-3,3a,4,5-tetrahydro-2H-benz[g]indole melting at 102°-104°.

1. customare consumed
2. filtrationThe mixture is filtered
3. customthe filtrate evaporated
4. dissolutionthe crude product dissolved in 500 ml of N hydrochloric acid
5. washThe solution is washed with diethyl ether
6. additiontreated with charcoal
7. filtrationfiltered
8. extractionIt is extracted with methylene chloride
9. customthe extract dried
10. customevaporated
11. customthe residue crystallized from petroleum ether
12. customrecrystallized from hexane