Pyridine → HCID 13533705, compound

Participants

Reaction Conditions

Reaction Steps

A 90 mg portion of 6-chloro-3,3'-bipyridine and 0.15 ml of anhydrous hydrazine were dissolved in 20 ml of pyridine and heated at 110° C. for 48 hours. The volatiles were removed at reduced pressure and the residue dissolved in 20 ml of triethyl orthoacetate and heated at 110° C. for 12 hours. The volatiles were removed at reduced pressure and the residue purified by chromatography on silica gel, eluting with ethyl acetate:methanol (9:2). The obtained tan solid was recrystallized from ethyl acetate-methanol, giving the desired product as off-white flakes, mp 199°-201.5° C.

Provenance & Evidence