Ethyl orthoformate → 7-(2-Pyridinyl)-1,2,4-triazolo[4,3-a]pyridine

Participants

Reaction Steps

A mixture of 2.0 g of 2'-hydrazino-2,4'-bipyridine and 50 ml of triethyl orthoformate was heated on a steam bath for 18 hours then chilled and filtered. The crystals were dissolved in methylene chloride, treated with activated carbon, filtered and the filtrate concentrated. Chilling and filtration gave 1.5 g of the desired product as cream colored crystals, mp 144-°145° C.

Provenance & Evidence