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HRID465181

反应详情

EQUATION

反应方程式

HRID 465181 的结构方程式

REACTANTS

反应物

2
结构：CNC(=S)[S-].[Na+]
HCID5366415

Metam-sodium

C2H4NNaS2

结构：CON=C(C(=O)NC(C(=O)NC1CN(S(=O)(=O)[O-])C1=O)c1csc(NC(=O)CCl)n1)c1csc(NC(=O)CCl)n1.[Na+]
HCID74088530

未命名化合物

PRODUCTS

生成物

1
结构：CON=C(C(=O)NC(C(=O)NC1CN(S(=O)(=O)[O-])C1=O)c1csc(N)n1)c1csc(N)n1.[Na+]
HCID74088536

未命名化合物

收率 63.3%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O
溶剂HCID962

Water

H2O

PROCEDURE

实验过程

In 3 ml of water is dissolved 0.204 g of the above sodium 3-[2-[2-(2-chloroacetamido-4-thiazolyl)-2-methoxyiminoacetamido]-2-(2-chloroacetamido-4-thiazolyl)acetamido]-2-oxoazetidine-1-sulfonate (syn-isomer) and while the solution is stirred under ice-cooling, 0.085 g of sodium N-methyldithiocarbamate is added. The mixture is stirred for an hour, after which the insoluble matter is filtered off. The filtrate is purified by Amberlite, XAD-II chromatography to provide 0.1 g of sodium 3-[2-[2-(2-amino-4-thiazolyl)-2-methoxyiminoacetamido]-2-(2-amino-4-thiazolyl)acetamido]-2-oxoazetidine-1-sulfonate (syn-isomer).

WORKUP

后处理

  1. temperaturecooling
  2. stirringThe mixture is stirred for an hour
  3. filtrationafter which the insoluble matter is filtered off
  4. customThe filtrate is purified by Amberlite, XAD-II chromatography