HCID 86740397, compound → HCID 86740403, compound

HRID 465207Notes

Reaction equation

HRID 465207 reaction equation
[C:1]([S:4][C@H:5]1[N:8]([S:9]([O-:12])(=[O:11])=[O:10])[C:7](=[O:13])[C@H:6]1[NH:14][C:15](=[O:30])[C:16]([C:20]1[N:21]=[C:22]([NH:25][C:26](=[O:29])[CH2:27]Cl)[S:23][CH:24]=1)=[N:17][O:18][CH3:19])(=[O:3])[CH3:2].[Na+:31].C(=S)(SC)[NH2:33].[Na]>O>[C:1]([S:4][C@H:5]1[N:8]([S:9]([O-:12])(=[O:11])=[O:10])[C:7](=[O:13])[C@H:6]1[NH:14][C:15](=[O:30])[C:16]([C:20]1[N:21]=[C:22]([NH:25][C:26](=[O:29])[CH2:27][NH2:33])[S:23][CH:24]=1)=[N:17][O:18][CH3:19])(=[O:3])[CH3:2].[Na+:31]

Participants

4

Reactant 2

HCID 86740397HCID 86740397, compoundHCID 86740405HCID 86740405, compound

Product 1

HCID 86740403HCID 86740403, compoundYield 16.6%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of 0.10 g of sodium (3R,4R)-4-acetylthio-3-[2-(2-chloroacetamidothiazol-4-yl)-2-methoxyiminoacetamido]-2-oxoazetidine-1-sulfonate in 5 ml of water is added under ice-cooling 0.030 g of sodium monomethyl dithiocarbamate, and the mixture is stirred for 3 hours at room temperature. The same procedure as Example 3B yields 0.016 g of sodium (3R,4R)-4-acetylthio-3-[2-(2-aminoacetamidothiazol-4-yl)-2-methoxyiminoacetamido]-2-oxoazetidine-1-sulfonate.

Sources & evidence

ORD record
ord-6adefe406621449bb62f10427dbe640b
Source dataset
uspto-grants-1985_10
Patent number
US04550105

Reaction notes

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