反应详情

A solution of 8.36 g of O,S-dimethyl phosphoro-isocyanatidothioate in 100 ml of ether was cooled to 0° C. and to it was added dropwise with stirring 7.15 g of methyl 3-piperidinecarboxylate. The mixture was allowed to warm to ambient temperature and react overnight. The precipitate that formed was collected by filtration, extracted with ether, and dried under reduced pressure to obtain 11.5 g (74 percent of theory) of the title compound as white crystals melting at 65°-67° C.

1. additionwas added dropwise
2. customreact overnight
3. customThe precipitate that formed
4. filtrationwas collected by filtration
5. extractionextracted with ether
6. customdried under reduced pressure