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HRID465302

反应详情

EQUATION

反应方程式

HRID 465302 的结构方程式

REACTANTS

反应物

3
结构：CCCCCCCCCCCCCCCC(=O)Cl
HCID8206

Hexadecanoyl chloride

C16H31ClO

结构：Cc1cn([C@H]2C[C@H](F)[C@@H](CO)O2)c(=O)[nH]c1=O
HCID33039

Alovudine

C10H13FN2O4

结构：CO.ClC(Cl)Cl
HCID21584188

Chloroform methanol

C2H5Cl3O

PRODUCTS

生成物

1
结构：CCCCCCCCCCCCCCCC(=O)OC[C@H]1O[C@@H](n2cc(C)c(=O)[nH]c2=O)C[C@@H]1F
HCID15228330

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：c1ccncc1
溶剂HCID1049

Pyridine

C5H5N

PROCEDURE

实验过程

At 0° C., 1.2 equivalents of palmitoyl chloride are added to a solution of 3'-deoxy-3'-fluorothymidine in pyridine. The solution is warmed slowly to room temperature. As soon as a thin layer chromatographic control (CHCl3 /methanol=95/5 on silica gel) shows a complete reaction, the solution is poured into ice water. The aqueous phase is decanted, the resulting oil is chromatographed on silica gel with chloroform eluent. The title compound is recovered from the suitable fractions by evaporation of the solvent. M.P. 65°-66° C. (cyclohexane).

WORKUP

后处理

  1. customa complete reaction
  2. customThe aqueous phase is decanted
  3. customthe resulting oil is chromatographed on silica gel with chloroform eluent
  4. customThe title compound is recovered from the suitable fractions by evaporation of the solvent