Water → HCID 10831201, compound

Participants

Reaction Steps

To a solution of 3.6 g of 2-(4-chlorophenyl)-9-methyl-2,4,4a,5,6,7-hexahydro-3H-thieno[2',3':6,7]cyclohepta[1,2-c]pyridazin-3-one in 30 ml of acetic acid is added 0.6 ml of bromine at 40° C. with stirring and the reaction mixture is stirred at 40-45° C. for 30 minutes. The mixture is poured into water and the resultant oil is collected by decantation. The crude product is subjected to column chromatography on silica gel and eluted with chloroform to give 1.27 g of 2-(4-chlorophenyl)-2,5,6,7-tetrahydro-9-methyl-3H-thieno[2',3':6,7]cyclohepta[1,2-c]pyridazin-3-one, melting at 149.5°-151° C.

Provenance & Evidence