反应详情

49.7 gr of methyl iodide dissolved in 43 ml of anhydrous toluene are added to a solution of 5.5 gr of 2-(2-furoyl)-4-methylpyridine in 35.5 ml of anhydrous acetone. The mixture is kept under reflux for ninety-six hours. Following this, it is cooled for twelve hours. 8.1 g (Yield: 84%) of 2-(2-furoyl)-1,4-dimethylpyridinium iodide (I) with a melting point of 190°-95° C. are removed by filtering. An analytical sample recrystallized from ethanol has a melting point of 202-3° C. Analysis calculated for C12H12NO2I: C: 43.78; H: 3.67; N: 4.25. Found: 43.76; H: 3.73; N: 4.50.

1. temperatureunder reflux for ninety-six hours
2. temperatureis cooled for twelve hours