反应详情

The 2-carboxy-4-hydroxy-6-bromoquinoline (5.42 g, 20 mmol) was slurried in 250 ml of light mineral oil and heated to 270°-295° C. for 10-15 minutes. The mixture was allowed to cool overnight, diluted with chloroform and filtered, and then washed with adequate amounts of chloroform, yielding 6-bromo-4-hydroxyquinoline.

1. temperatureheated to 270°-295° C. for 10-15 minutes
2. temperatureto cool overnight
3. filtrationfiltered
4. washwashed with adequate amounts of chloroform