2-Chloroaniline → HCID 178516443, compound

HRID 465336Notes

Reaction equation

[Cl:1][C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].[C:9](C(OC)=O)#[C:10][C:11](OC)=[O:12]>>[Cl:1][C:2]1[CH:8]=[CH:7][CH:6]=[C:5]2[C:3]=1[N:4]=[CH:9][CH:10]=[C:11]2[OH:12]

Participants

Reactant 2

HCID 72402-Chloroaniline

HCID 12980Dimethyl acetylenedicarboxylate

Product 1

HCID 178516443HCID 178516443, compound

Procedure

In the manner of Examples III.A. and B., 8-chloro-4-hydroxyquinoline was prepared from 2-chloroaniline and dimethyl acetylenedicarboxylate.

Sources & evidence

ORD record: ord-31a6665107e44a55ad77cd9e8ef98928
Source dataset: uspto-grants-1992_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05153196

Reaction notes

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