HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[(1R)-1-hydroxyethyl]-4-methyl-3,7-dioxo-, (4-nitrophenyl)methyl ester, (4R,5R,6S)- → HCID 131717558, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[(1R)-1-hydroxyethyl]-4-methyl-3,7-dioxo-, (4-nitrophenyl)methyl ester, (4R,5R,6S)- | HCID 9885302 | — |
| Reactant | HCID 57214107 | HCID 57214107 | — |
| Product | HCID 131717558 | HCID 131717558 | — |
Reaction Steps
In the same manner as described in Example 29-(1), (1R, 5R, 6S)-6-[(1R)-1-hydroxyethyl]-1-methyl-2-oxo-carbapenam-3-carboxylic acid 4-nitrobenzyl ester is treated with (4S)-N-methyl-4-mercaptopyrrolidine-2-thione to give (1R, 5S, 6S)-2-[(4S)-N-methylpyrrolidine-2-thion-4-ylthio]-6-[(1R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylic acid 4-nitrobenzyl ester as an amorphous powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05153187 |
| Source dataset | uspto-grants-1992_10 |
| ORD ID | ord-d0898ba314384dad9a452211aa506f77 |
| Source note | uspto-grants-1992_10 |