HuagongsheHuagongshe Chemistry Print Report · For research reference only
Iodomethyl 2-methylpropanoate → (1R, 5S, 6S)-2-[(3S)-pyrrolidine-2-thion-3-ylthio]-6-[(1R)-1-hydroxyethy l]-1-methylcarbapen-2-em-3-carboxylic acid isobutyryloxymethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Iodomethyl 2-methylpropanoate | HCID 10376456 | — |
| Reactant | (1R, 5S, 6S)-2-[(3S)-pyrrolidine-2-thion-3-ylthio]-6-[(1R)-1-hydroxyethyl]-1-met hylcarbapen-2em-3-carboxylic acid potassium salt | HCID 131717564 | — |
| Product | (1R, 5S, 6S)-2-[(3S)-pyrrolidine-2-thion-3-ylthio]-6-[(1R)-1-hydroxyethy l]-1-methylcarbapen-2-em-3-carboxylic acid isobutyryloxymethyl ester | HCID 131717563 | — |
Reaction Steps
In the same manner as described in Example 48, (1R, 5S, 6S)-2-[(3S)-pyrrolidine-2-thion-3-ylthio]-6-[(1R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylic acid potassium salt is treated with isobutyryloxymethyl iodide to give (1R, 5S, 6S)-2-[(3S)-pyrrolidine-2-thion-3-ylthio]-6-[(1R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylic acid isobutyryloxymethyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05153187 |
| Source dataset | uspto-grants-1992_10 |
| ORD ID | ord-8b1dfb2968874938bcc5a9879a3090b8 |
| Source note | uspto-grants-1992_10 |