Methyl iodide → 2-(2-Furoyl)-1,4-dimethylpyridinium iodide

HRID 46535Notes

Reaction equation

[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([C:8]1[CH:13]=[C:12]([CH3:14])[CH:11]=[CH:10][N:9]=1)=[O:7].[CH3:15][I:16]>>[I-:16].[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([C:8]1[CH:13]=[C:12]([CH3:14])[CH:11]=[CH:10][N+:9]=1[CH3:15])=[O:7]

Participants

Reactant 2

HCID 6328Methyl iodide

HCID 203875722-(2-Furoyl)-4-methylpyridine

Product 1

HCID 203875702-(2-Furoyl)-1,4-dimethylpyridinium iodide

Procedure

A process for preparing 2-(2-furoyl)-1,4-dimethylpyridinium iodide comprising the steps of reacting 2-cyano-4-methylpyridine under a nitrogen atmosphere with an ethereal solution of freshly prepared 2-furyl-lithium, hydrolyzing the reaction mixture under acid conditions to form 2-(2-furoyl)-4-methylpyridine, and heating the 2-(2-furoyl)-4--methylpyridine in the presence of methyl iodide to form 2-(2-furoyl)-1,4-dimethylpyridinium iodide.

Sources & evidence

ORD record: ord-5b0f895c6c204c92bee99b40c64d00a1
Source dataset: uspto-grants-1979_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04173705

Reaction notes

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