Methanesulfonyl chloride → HCID 53812316, compound

Participants

Reaction Steps

To a solution of 2-(2,3-dimethoxystyryl)-4,5,6,7-tetrahydrothiazolo[5,4-b]pyridine (1.0 g, 3.3 mmole) in pyridine (10 ml) was added dropwise methanesulfonyl chloride (0.45 g, 3.97 mmole) with ice-cooling. The reaction mixture was heated with stirring at room temperature for 3 hours and then a sodium bicarbonate solution was added to the mixture which was extracted with a chloroform-methanol mixed solvent. The extract was dried over magnesium sulfate and concentrated. The residue was purified by flash column chromatography and recrystallized from hexane-ethyl acetate to obtain the title compound (1.09 g, yield: 92.7%).

Provenance & Evidence