HCID 67831620, compound → HCID 10134087, compound

HRID 465371Notes

Reaction equation

HRID 465371 reaction equation
[ClH:1].[C:2]1([CH:8]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[O:9][CH:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][C:18]([O:20]CC)=[O:19])[CH2:12][CH2:11]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CO.[OH-].[Na+]>[ClH:1].[C:23]1([CH:8]([C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[O:9][CH:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][C:18]([OH:20])=[O:19])[CH2:12][CH2:11]2)[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1

Participants

4

Reactant 1

HCID 67831620HCID 67831620, compound

Product 1

HCID 10134087HCID 10134087, compoundYield 88.1%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

A mixture of 3.22 g of ethyl 4-(diphenylmethoxy)-1-piperidinepropionate hydrochloride in 30 ml of methanol and 12.0 ml of 2N sodium hydroxide aqueous solution was refluxed for 1 hour and concentrated. Water was added to the residue and made acidic with hydrochloric acid. The precipitate was collected by filtration and recrystallized from water to give 2.64 g of colorless needles, mp 183°~185° C.

Workup

  1. temperaturewas refluxed for 1 hour
  2. concentrationconcentrated
  3. additionWater was added to the residue
  4. filtrationThe precipitate was collected by filtration
  5. customrecrystallized from water

Sources & evidence

ORD record
ord-255c1a91036d42ab9a5df12f4eaa83f6
Source dataset
uspto-grants-1992_10
Patent number
US05153207

Reaction notes

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