1-Cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid → HCID 15021560, compound

HRID 465385Notes

Reaction equation

HRID 465385 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([F:13])[C:11]=1F)[N:8]([CH:14]1[CH2:16][CH2:15]1)[CH:7]=[C:6]([C:17]([OH:19])=[O:18])[C:5]2=[O:20]>C(O)(=O)C>[CH3:14][N:8]1[CH2:9][CH2:4][CH:5]([O:20][C:11]2[C:10]([F:13])=[C:9]3[C:4]([C:5](=[O:20])[C:6]([C:17]([OH:19])=[O:18])=[CH:7][N:8]3[CH:14]3[CH2:16][CH2:15]3)=[CH:3][C:2]=2[F:1])[CH2:6][CH2:7]1

Participants

3

Reactant 1

HCID 5354141-Cyclopropyl-6,7,8-trifluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Product 1

HCID 15021560HCID 15021560, compoundYield 42%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

6,7,8-Trifluoro-1-cyclopropyl-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid (570 mg) was reacted in a similar manner to Example 9. Acetic acid (480 mg) was added and DMF was distilled off under reduced pressure. The residue was purified by columnchromatography on silica gel, whereby 160 mg of the title compound was obtained.

Workup

  1. distillationDMF was distilled off under reduced pressure
  2. customThe residue was purified by columnchromatography on silica gel

Sources & evidence

ORD record
ord-d648e408bd4141bd89be949eabf6ae77
Source dataset
uspto-grants-1992_10
Patent number
US05153203

Reaction notes

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