Ethanol → HCID 19874143, compound

HRID 465396Notes

Reaction equation

HRID 465396 reaction equation
[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:30])=[C:11]([N:15]4[CH2:19][CH:18]([CH2:20][O:21]C(=O)C5C=CC=CC=5)[O:17][CH2:16]4)[C:12]=3[F:14])[C:7](=[O:31])[C:6]([C:32]([O:34]CC)=[O:33])=[CH:5]2)[CH2:3][CH2:2]1.C(O)C.C(=O)([O-])[O-].[Na+].[Na+]>C(O)(=O)C>[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:30])=[C:11]([N:15]4[CH2:19][CH:18]([CH2:20][OH:21])[O:17][CH2:16]4)[C:12]=3[F:14])[C:7](=[O:31])[C:6]([C:32]([OH:34])=[O:33])=[CH:5]2)[CH2:2][CH2:3]1

Participants

5

Reactant 3

HCID 702EthanolHCID 10340Sodium CarbonateHCID 19874148HCID 19874148, compound

Product 1

HCID 19874143HCID 19874143, compoundYield 88.2%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 250 mg of ethyl 1-cyclopropyl-6,8-difluoro-7-(5-benzoyloxymethyl-3-oxazolidinyl)-1,4-dihydro-4-oxoquinoline-3-carboxylate, 2 ml of ethanol and 10 ml of 10% aq. sodium carbonate solution was stirred under reflux for 1 hour. The reaction mixture was allowed to cool down and then acidified with acetic acid. Crystals thus precipitated were collected by filtration. They were washed with water and ethanol and then dried, whereby 162 mg of the title compound was obtained.

Workup

  1. temperatureunder reflux for 1 hour
  2. temperatureto cool down
  3. customCrystals thus precipitated
  4. filtrationwere collected by filtration
  5. washThey were washed with water and ethanol
  6. customdried

Sources & evidence

ORD record
ord-5f1b528545a34a0bbfd799f6e3fb432a
Source dataset
uspto-grants-1992_10
Patent number
US05153203

Reaction notes

Loading…