反应详情

温度

30 °C

Into a mixture of 150 ml of Raney nickel (activated type, produced by Aldrich Co.), which had been washed with water and then ethanol, and 750 ml of ethanol, was added 15.06 g (37.9 mmol) of dithioethyleneketal of methyl 4-tridecanoylpyrrole-2-carboxylate obtained in Synthesis Example 2. The mixture was refluxed for 30 minutes and cooled to about 30° C. After removing Raney nickel, the mixture was evaporated. The residue was recrystallized from ethanol to obtain 10.70 g of methyl 4-tridecylpyrrole-2-carboxylate as white crystals. The yield was 91.8% and the melting point was 80° to 82° C.

1. washhad been washed with water
2. customobtained in Synthesis Example 2
3. temperatureThe mixture was refluxed for 30 minutes
4. customAfter removing Raney nickel
5. customthe mixture was evaporated
6. customThe residue was recrystallized from ethanol