反应详情

A solution of 2-[4-acetonylphenoxymethyl]-5-hydroxy-4H-pyran-4-one (1.0 g) and 2-(4-amino-3,5-dichlorophenyl)-2-hydroxyethylamine (0.75 g) in benzene, was heated to reflux for 3 hours under a Dean and Stark head. After cooling, the solvent was removed in vacuo, the residue dissolved in methanol, treated with sodium cyanoborohydride (0.25 g) and then stirred at ambient temperature for 18 hours. The solvent was evaporated under reduced pressure and the residue taken up in ethyl acetate and washed with water (2×50ml), brine (1×50 ml) and dried (MgSO4). After filtration and evaporation of solvent the residue was purified by column chromatography on silica using 3% methanol:chloroform as eluent to give 2-[4-[2-[(4-amino-3,5-dichloro-β-hydroxyphenethyl)amino]propyl]phenoxymethyl]-5-hydroxy-4H-pyran-4-one as a (40:60) mixture of diastereoisomers.

1. temperatureto reflux for 3 hours under a Dean and Stark head
2. temperatureAfter cooling
3. customthe solvent was removed in vacuo
4. dissolutionthe residue dissolved in methanol
5. additiontreated with sodium cyanoborohydride (0.25 g)
6. customThe solvent was evaporated under reduced pressure
7. washwashed with water (2×50ml), brine (1×50 ml)
8. dry with materialdried (MgSO4)
9. filtrationAfter filtration and evaporation of solvent the residue
10. customwas purified by column chromatography on silica using 3% methanol