3,4-dihydro-5-(4-acetonyloxyphenyl) 6-methyl-2(1H)-pyridinone → 5-[4-[2-[(3-Chloro-beta-hydroxyphenethyl)amino]propyloxy]phenyl]-3,4-dihydro-6-methyl-2(1H)-pyridinone

Participants

Reaction Steps

5-[4-[2-[(3-Chloro-β-hydroxyphenethyl)amino]propyloxy]phenyl]-3,4-dihydro-6-methyl-2(1H)-pyridinone was prepared as a 1:1 mixture of diastereoisomers, m.pt. 99°-104° C., from 2-hydroxy-2-(3-chlorophenyl)ethanamine carbonate (0.58 g) and 3,4-dihydro-5-(4-acetonyloxyphenyl) 6-methyl-2(1H)-pyridinone (0.75 g) in an analogous manner to the compound described in Example 38.

Provenance & Evidence