HCID 19874578, compound → HCID 19874518, compound

Participants

Reaction Steps

A solution of 4-benzyloxy-α-[[[2-[4-((4,5-dihydro-1H-2-imidazolyl)methyloxy)phenoxy]-1-methylethyl]amino]methyl]benzenemethanol (1.5 g) in ethylacetate (80 ml) was hydrogenated at atmospheric pressure in the presence of 10% palladium on carbon. The reaction mixture was filtered and evaporated to a foam which was purified by column chromatography on alumina. Elution with methanol-chloroform (8:92) gave 4-hydroxy-α [[[2-[4-((4,5-dihydro-1H-2-imidazolyl)-methyloxy)phenoxy]-1-methylethyl]amino]methyl]benzene-methanol m.pt. 160°-180° C. (ethyl acetate), as a 40:60 mixture of diastereoisomers.

Provenance & Evidence