Ethylene Glycol → HCID 19874512, compound

Participants

Reaction Steps

A mixture of 1,4-phenylene bis(propan-2-one), (17.12 g), ethane-1,2-diol (1.72 g) and a trace of 4-toluene sulphonic acid was heated under reflux in benzene for 2 hr. using a Dean and Stark apparatus. The solvent was evaporated and the residue chromatographed on silica. Elution with 1:3 diethyl ether:petrolroleum ether (40-60) gave 4-(2,2-(ethylenedioxy)propyl)phenyl propan-2-one, as a white solid (3.5 g). Further elution gave starting material (12.9 g).

Provenance & Evidence