Sodium Bicarbonate → HCID 56987681, compound

Participants

Reaction Steps

4-[4-(2,2-Ethylenedioxypropyl)phenyl piperidin-4-ol (0.9 g) was dissolved in 50% hydrochloric acid solution, and heated under reflux for 4 hr. The solution was cooled, basified with 1.2M sodium bicarbonate solution and extracted with ethylacetate (3×50 ml). The organic extract was dried (magnesium sulphate), filtered and evaporated in vacuo, to give an oil which was chromatographed on silica. Elution with chloroform:methanol (97:3) gave 4-(1,2,3,6-tetrahydropyridyl) phenyl propan-2-one (0.5 g).

Provenance & Evidence